Life connected au des while technology evolves by design?

Friday, July 22, 2011

'Cellular Housekeeping' for Health and Longevity

Over time many things can accumulate in cells to the point at which they are a burden. Some of these are defunct organelles and even prions and amyloid1, the protein aggregate characterizing the physical pathology of Alzheimer's disease. Inducing autophagy causes cells to break down for sustenance such junk. Autophagy is normally a response to starvation but can be stimulate by consuming trehalose, as MIT graduate and decades-long nanotechnology icon Eric Drexler provides credible sources demonstrating on his 'metamodern' blog.

I first heard about inducing autophagy for this purpose in Timothy Ferriss's The 4-Hour Body. He recommends periodically adopting a lysine-deficient diet to induce autophagy2, suggesting that the deprivation of only one essential amino acid is enough to cause cells to start scavenging nutrients from non-essential structures in their organism. He immediately continues to write that regular phlebotomy decreases the likelihood of men and post-menopausal women having heart attacks due to excess iron3. He suggests scheduling to have extra plasma taken and drinking a cup of coffee just before donating it (the paraxanthine metabolite of caffeine releases toxins stored in body lipids4) and that regularly getting blood drawn not only decreases such demographics' risks of death from causes besides cardiovascular incidents but also improves their insulin sensitivity5.

1http://metamodern.com/2010/09/15/trehalose-autophagy-and-brain-repair-sweet/
2http://books.google.com/books?id=yeIGdYQQNQsC&pg=PT963&lpg=PT963&dq=lysine+autophagy+timothy+ferriss&source=bl&ots=2bIgFynxO2&sig=k07apnQsYMetFvGGnKj-IVcrfNc&hl=en&ei=Z-0oTtOwDOfV0QHEoZ3ICg&sa=X&oi=book_result&ct=result&resnum=1&sqi=2&ved=0CBUQ6AEwAA#v=onepage&q&f=false
3http://www.livestrong.com/article/439708-heart-disease-in-men-iron/
4http://www.ncbi.nlm.nih.gov/pubmed/2312486
5http://www.ncbi.nlm.nih.gov/pubmed/17391316

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